Chemical Name:(S)-7-Hydroxy Warfarin-d5
Synonyms:4,7-Dihydroxy-3-[(1S)-3-oxo-1-(phenyl-d5)butyl]-2H-1-benzopyran-2-one; (S)-4,7-Dihydroxy-3-(3-oxo-1-(phenyl-d5)butyl)2H-1-benzopyran-2-one; 7-Hydroxy-S-warfarin-d5; S-7-Hydroxywarfarin-d5;
Alternate CAS #:63740-81-8 unlabelled
Molecular Formula:C₁₉H₁₁D₅O₅
Molecular Weight:329.36
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(S)-7-Hydroxy Warfarin-d5 is the labelled analogue of (S)-7-Hydroxy Warfarin (H996126), the S-enantiomer of the 7-hydroxyl metabolite of Warfarin (W498500). (S)-7-Hydroxy Warfarin was present at levels 7-folds higher in chimeric mice with humanized liver (than that in controlled mice) following (S)-Warfarin metabolism.
References:Wong, Y.W.J. et al.: Pharm. Res., 6, 982 (1989); O’Reilly, R.A. et al.: Clin. Pharmacol. Ther., 51, 656 (1992); Inoue, T. et al: Drug Metab. Dispos. 36, 2429 (2008);
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