Chemical Name:L,L-Dityrosine-13C12 Dihydrochloride
Synonyms:(α3S,α3’S)-α3,α3′-Diamino-6,6′-dihydroxy-[1,1′-biphenyl]-3,3′-dipropanoic Acid-13C12; [S-(R*,R*)]-α,α’-Diamino-6,6′-dihydroxy-[1,1′-biphenyl]-3,3′-dipropanoic Acid-13C12; 3,3′-Bityrosine Dihydrochloride; 3,3′-Dityrosine-13C12; Bityrosine-13C12; Dityrosine-13C12; o,o-Dityrosine-13C12; o,o’-Dityrosine-13C12;
Alternate CAS #:221308-01-6 Unlabelled
Molecular Formula:C₆¹³C₁₂H₂₂Cl₂N₂O₆
Molecular Weight:445.19
Category:Research Tools; Isotopic Labeled Analogues; Molecular Biology; Fluorescent Reagents; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Labeled Dityrosine (D494290) (DY), a tyrosine dimer formed by 3,3’-biaryl bond formation can be used as a biomarker to detect oxidative protein damage and selective proteolysis. Fluorescence intensity decays of Dityrosine are generally characterized by two decay components, one with a lifetime in the range of 150 to 800 ps and another between 2.5 and 4.5 ns.
References:Libertini, L., et al.: Biophys. J., 47, 765 (1985), Huggins, T., et al.: J. Biol. Chem., 268, 12341 (1993), Malencik, D., et al.: Biochemistry, 35, 4375 (1996),
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