Chemical Name:KU-60019
Synonyms:2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide
CAS Number:925701-46-8
Alternate CAS #:Deleted: 925701-49-1, 894104-72-4
Molecular Formula:C₃₀H₃₃N₃O₅S
Molecular Weight:547.67
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:KU-60019 is a potent and reversible inhibitor of ATM kinase, blocking the phosphorylation of ATM substrate proteins. It sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro.
References:Golding, S. et al.: Mol. Cancer Ther., 8, 2894 (2009); Golding, S. et al.: Mol. Cancer Ther, 8, 10 (2012);
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