Chemical Name:Ethyl (2E,4S)-4,5-Isopropylidenedioxy-2-methylpent-2-enoate
CAS Number:81997-76-4
Molecular Formula:C₁₁H₁₈O₄
Molecular Weight:214.26
Category:Building Blocks; Miscellaneous;
Applications:Ethyl (2E,4S)-4,5-isopropylidenedioxy-2-methylpent-2-enoate can be used for the synthesis of 2′-deoxy-2′-fluoro-2′-C-methylcytidine (I) (PSI-6130), which is a potent and selective inhibitor of HCV NS5B polymerase and marine dolabellane diterpenoids (ie. claenone (I), palominol (II), and dolabellatrienone (III)). It also has potential applications for the synthesis of related antiviral agents.
References:Wang P., et al.: J. Org. Chem. 74, 6819 (2009); Wang, P., et al.: PCT Int. Appl. WO 2006012440 A2 20060202 (2006); Miyaoka, H., et al.: Tetrahedron 59, 61 (2002).
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