Chemical Name:ent-Emtricitabine Triphosphate Triethylammonium Salt
Synonyms:P-[[(2S,4R)-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolan-2-yl]methyl] Ester Triphosphoric Acid Triethylammonium Salt; (2S-cis)-P-[[5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolan-2-yl]methyl] Ester Triphosphoric Acid Triethylammonium Salt; Triphosphoric Acid Deriv. 1,3-Oxathiolane Triethylammonium Salt
Molecular Formula:C₈H₁₃FN₃O₁₂P₃S . (C₆H₁₅N)ₓ
Molecular Weight:487.19 . (101.19)x
Category:Standards; Enzyme Activators and Inhibitors;
Applications:ent-Emtricitabine Triphosphate Triethylammonium Salt is a metabolite of ent-Emtricitabine (E525005). The free acid, ent-Emtricitabine Triphosphate inhibits the prodn. of full-length minus-strand DNA in an endogenous reverse transcriptase reaction, inhibits DNA synthesis, and can be used as a chain-terminating substrate.
References:Wilson, J., et al.: Antimicrob. Agents Chemother., 37, 1720 (1993)
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