Chemical Name:EHop-016
Synonyms:N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-morpholinopropyl)pyrimidine-2,4-diamine; N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine
CAS Number:1380432-32-5
Molecular Formula:C₂₅H₃₀N₆O
Molecular Weight:430.55
Category:Research Tools;
Applications:EHop-016 is a rac GTPase inhibitor. EHop-016 is a compound that blocks the interaction of Rac with the GEF Vav in metastatic human breast cancer cells. EHop-016 also inhibits the activation of the Rac downstream effector p21-activated kinase, extension of motile actin-based structures, and cell migration.
References:Montalvo-Ortiz, B.L., et al.: J. Biol. Chem., 287, 13228 (2012); Dharmawardhane, S., et al.: Enzymes, 33, 117 (2013)
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