CAS:936481-23-1|(2’R)-N2′-Deacetyl-N2′-[3-(methylthio)-1-oxopropyl]-maytansine

Catalogue Number:D199038
Chemical Name:(2’R)-N2′-Deacetyl-N2′-[3-(methylthio)-1-oxopropyl]-maytansine
CAS Number:936481-23-1
Molecular Formula:C₃₆H₅₀ClN₃O₁₀S
Appearance:White Solid
Molecular Weight:752.31
Storage:-20°C
Solubility:Chloroform, DCM, Methanol
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(2’R)-N2′-Deacetyl-N2′-[3-(methylthio)-1-oxopropyl]-maytansine is an epimer of N2′-Deacetyl-N2′-[3-(methylthio)-1-oxopropyl]-maytansine (D199035), which is an active metabolite of Maytansine (M197940), inhibits in vitro polymerization of tubulin and is used in the treatment of advanced breast cancer.
References:Remillard, S., et. al.: Science, 189, 1002 (1975); Prota, A.E., et. al.: P. Natl. Acad. Sci. USA, 111, 13817 (2014);
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