Catalogue Number:D226245
Chemical Name:4-Dechloro-3-chloro indomethacin
Synonyms:1-(3-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid;
CAS Number:807614-94-4
Molecular Formula:C₁₉H₁₆ClNO₄
Appearance:Pale Pink Solid
Melting Point:109 – 112oC
Molecular Weight:357.79
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:4-Dechloro-3-chloroindomethacin is an impurity of Indomethacin (I641000) which inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO).
References:Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)
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