Catalogue Number:B234510
Chemical Name:3-O-(tert-Butyldimethylsilyl) Estrone
Synonyms:Estrone tert-Butyldimethylsilyl Ether; 3-(t-Butyldimethylsiloxy)estra-1,3,5(10)-trien-17-one
CAS Number:57711-40-7
Molecular Formula:C₂₄H₃₆O₂Si
Appearance:White solid
Molecular Weight:384.64
Solubility:Dichloromethane
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:3-O-(tert-Butyldimethylsilyl) Estrone is an intermediate in the synthesis of ∆9,11-Dehydro-17a-cyanomethyl Estradiol (D229505) which is a metabolite of progestin dienogest (D441870), and is currently being investigated for progesterone-receptor binding, progestational, antiprogestational, estrogenic and antigonadotropic activities for the inhibition of fertility. It is also being considered a novel treatment for heavy menstrual bleeding.
References:Oettel, M., et al.: Pharmazie, 41, 627 (1993); Kiley, J. & Shulman, L.: Int. J. Womens Health, 3, 281 (2011);
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