Catalogue Number:B330240
Chemical Name:Betulin
Synonyms:Lup-20(29)-ene-3β,28-diol; Lup-20(30)-ene-3β,28-diol; 3aH-Cyclopenta[a]chrysene, lup-20(29)-ene-3,28-diol deriv.; (+)-Betulin; 3,28-Dihydroxy-lupeol; 3β,28-Dihydroxylup-20(29)-ene; Betulin; Betuline; Betulinic alcohol; Betulinol; Betulol; NSC 4644; Trochol
CAS Number:473-98-3
Molecular Formula:C₃₀H₅₀O₂
Appearance:Pale Beige to Brown Solid
Melting Point:>250°C (dec.)
Molecular Weight:442.72
Storage:-20°C, Hygroscopic
Solubility:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Betulin is a derivative of Betulinic Acid (B330250), used in the treatment of cancer and HIV disease. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity
References:Cichewicz, R. et al.: Med. Res. Rev., 24, 90 (2003); Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010);
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