CAS:2504210-40-4|N-((3S,4S)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Catalogue Number:B250420
Chemical Name:N-((3S,4S)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Synonyms:N-​Methyl-​N-​[(3S,​4S)​-​4-​methyl-​1-​(phenylmethyl)​-​3-​piperidinyl]​-​7-​[(4-​methylphenyl)​sulfonyl]​-7H-​pyrrolo[2,​3-​d]​pyrimidin-​4-​amine
CAS Number:2504210-40-4
Category:Building Blocks; Enzyme Activators and Inhibitors;
Applications:N-((3S,4S)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine is an intermediate in the synthesis of Tofacitinib impurity P (T528025), an impurity of Tofacitinib (T528000), an enantiopure stereoisomer of the drug, Janus kinase 3(Jak3) inhibitor (CP-690,550) that has been found to inhibit selected members of the STE7 and STE20 subfamily of kinases.
References:Jiang, J., et. al.: J. med. Chem., 51, 8012 (2008)
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