Catalogue Number:B287516
Chemical Name:(2R,4S)-Benzyl 5-oxo-2,4-diphenyloxazolidine-3-carboxylate
Synonyms:Benzyl (2R,4S)-5-Oxo-2,4-diphenyl-1,3-oxazolidine-3-carboxylate; Intermediate of Rolapitant
CAS Number:205654-80-4
Molecular Formula:C₂₃H₁₉NO₄
Molecular Weight:373.4
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(2R,4S)-Benzyl 5-oxo-2,4-diphenyloxazolidine-3-carboxylate is an intermediate in the preparation of Rolapitant (R639800). Rolapitant is an NK1 receptor antagonist that is used in the treatment of chemotherapy-induced nausea and vomiting.
References:Rojas, C. et al.: Cancer Treat. Rev., 41, 904 (2015); Navari, R. et al.: Exp. Rev. Anticanc. Ther., 15, 1127 (2015);
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