Catalogue Number:B234515
Chemical Name:3-O-(tert-Butyldimethylsilyl) 13,14-Dehydro Estrone
Synonyms:3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]estra-1,3,5(10),9(11)-tetraen-17-one
CAS Number:164734-71-8
Molecular Formula:C₂₄H₃₄O₂Si
Molecular Weight:382.62
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:3-O-(tert-Butyldimethylsilyl) 13,14-Dehydro Estrone is an intermediate in the synthesis of ∆9,11-Dehydro-17α-cyanomethyl Estradiol (D229505) which is a metabolite of progestin dienogest (D441870), and is currently being investigated for progesterone-receptor binding, progestational, antiprogestational, estrogenic and antigonadotropic activities for the inhibition of fertility. It is also being considered a novel treatment for heavy menstrual bleeding.
References:Oettel, M., et al.: Pharmazie, 41, 627 (1993); Kiley, J. & Shulman, L.: Int. J. Womens Health, 3, 281 (2011);
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