Catalogue Number:C994760
Chemical Name:L-Cysteinyl-L-cysteinyl-L-a-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-Tyrosine Trifluoroacetate
Synonyms:Linaclotide Linear Trifluoroacetate
CAS Number:1638632-09-3
Alternate CAS #
742095-77-8 free amine
Molecular Formula:C₆₁H₈₆F₃N₁₅O₂₃S₆
Appearance:White to Off-White Solid
Melting Point:>192°C (dec.)
Molecular Weight:1646.81
Storage:-20°C, Inert atmosphere
Solubility:DMSO (Slightly), Methanol (Slightly), Water (Very Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:L-Cysteinyl-L-cysteinyl-L-a-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-Tyrosine is a derivative of Linaclotide (L465880), a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
References:Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012)
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