CAS:143225-31-4|1,1-Dimethylethyl Ester [(1S,2S)-2-Hydroxy-3-[(2-methylpropyl)amino]-1-(phenylmethyl)propyl]carbamic Acid

Catalogue Number:D143225
Chemical Name:1,1-Dimethylethyl Ester [(1S,2S)-2-Hydroxy-3-[(2-methylpropyl)amino]-1-(phenylmethyl)propyl]carbamic Acid
Synonyms:[S-(R*,R*)]-[2-Hydroxy-3-[(2-methylpropyl)amino]-1-(phenylmethyl)propyl]-1,1-dimethylethyl Ester Carbamic Acid
CAS Number:143225-31-4
Molecular Formula:C₁₉H₃₂N₂O₃
Appearance:White Solid
Molecular Weight:336.47
Storage:-20°C
Solubility:Dichloromethane
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:1,1-Dimethylethyl Ester [(1S,2S)-2-Hydroxy-3-[(2-methylpropyl)amino]-1-(phenylmethyl)propyl]carbamic Acid is an intermediate in the synthesis of 2-epi-Darunavir (D193530), which is a stereoisomer to Darunavir (D193500), a second generation HIV-1-protease inhibitor
References:Rao, R.N., et. al.: J. Sep. Sci., 35, 2671 (2012); Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003); Arasteh, K., et al.: AIDS, 19, 943 (2005); Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005)
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