Catalogue Number:C596195
Chemical Name:1-(4-Chloro-3-trifluoromethylphenyl)-3-(4-hydroxyphenyl)urea
Synonyms:N-[4-Chloro-3-(trifluoromethyl)phenyl]-N’-(4-hydroxyphenyl)urea
CAS Number:1129683-83-5
Molecular Formula:C₁₄H₁₀ClF₃N₂O₂
Appearance:White to Light Yellow Solid
Melting Point:204-206°C
Molecular Weight:330.69
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:1-(4-Chloro-3-trifluoromethylphenyl)-3-(4-hydroxyphenyl)urea is an impurity of Sorafenib (S676850), a kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis.
References:Richly, H., et al.: Int. J. Clin. Pharmacol. Ther., 41, 620 (2003), Khire, U.R., et al.: Bioorg. Med. Chem. Lett., 14, 783 (2004), Wilhelm, S.M., et al.: Cancer Res., 64, 7099 (2004), Rini, B.I., et al.: Expert Opin. Pharmacother., 7, 453 (2006),
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