Chemical Name:AR-42
Synonyms:(αS)-N-[4-[(Hydroxyamino)carbonyl]phenyl]-α-(1-methylethyl)benzeneacetamide; (S)-(+)-N-Hydroxy-4-(3-methyl-2-phenyl-butyrylamino)-benzamide; (S)-HDAC 42; OSU-HDAC 42
CAS Number:935881-37-1
Molecular Formula:C₁₈H₂₀N₂O₃
Molecular Weight:312.36
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:AR-42 is a broad spectrum deacetylase inhibitor of both histone and non-histone proteins, which has demonstrated greater potency and activity in solid tumors and hematological malignancies. AR-42 is known utilized as a novel, oral cancer therapy currently in early clinical development.
References:Bai, L.Y., et al.: Oral. Oncol., 47, 1127 (2011); Huang, P.H., et al.: Molec. Cellular. Pharmacol., 3, 39 (2011);
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