Chemical Name:9-Chloro-4,7-diaza-nonyl Ethyl Phosphate
Synonyms:3-((2-((2-Chloroethyl)amino)ethyl)amino)propyl Ethyl Hydrogen Phosphate
Molecular Formula:C₉H₂₂ClN₂O₄P
Molecular Weight:288.71
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:9-Chloro-4,7-diaza-nonyl Ethyl Phosphate is an impurity of Cyclophosphamide Monohydrate (C988580); a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase (ALDH) 1 activity. This substance is listed as a known human carcinogen.This compound is suitable for aldehyde dehydrogenase (ALDH) related research.
References:Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962); Fraiser, L.H., et al.: Drugs, 42, 781 (1991); Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999)
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