5-Fluoro-4-(7′-fluoro-2′-methylspiro[cyclopentane-1,3′-[3H]indol]-5′-yl)-N-[5-(1-methyl-4-piperidinyl)-2-pyridinyl]-2-pyrimidinamine

Chemical Name:5-Fluoro-4-(7′-fluoro-2′-methylspiro[cyclopentane-1,3′-[3H]indol]-5′-yl)-N-[5-(1-methyl-4-piperidinyl)-2-pyridinyl]-2-pyrimidinamine
Synonyms:5-Fluoro-4-(7′-fluoro-2′-methylspiro[cyclopentane-1,3′-indol]-5′-yl)-N-(5-(1-methylpiperidin-4-yl)pyridin-2-yl)pyrimidin-2-amine
CAS Number:2099128-41-1
Molecular Formula:C₂₈H₃₀F₂N₆
Molecular Weight:488.57
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:5-Fluoro-4-(7′-fluoro-2′-methylspiro[cyclopentane-1,3′-[3H]indol]-5′-yl)-N-[5-(1-methyl-4-piperidinyl)-2-pyridinyl]-2-pyrimidinamine is a novel CDK4/6 inhibitor which is designed to overcome blood brain barrier in gliobastoma therapy.
References:Yin, L., et al.: Eur. J. Med. Chem., 144,1(2018)
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