Chemical Name:4-Deschloro-4-bromo-losartan Potassium Salt
Synonyms:Potassium 5-(4′-((4-bromo-2-butyl-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-2-ide;
Alternate CAS #:Free Base: 124749-81-1
Molecular Formula:C₂₂H₂₂BrKN₆O
Molecular Weight:505.45
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:4-Deschloro-4-bromo-losartan Potassium Salt is an impurity in the preparation of Losartan (L470500), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
References:Chiu, T.A., et al.: J. Pharmacol. Exp. Ther., 252, 711 (1990), McIntyre, M., et al.: Pharmacol. Ther., 74, 181 (1997), Pitt, B., et al.: Lancet, 355, 1582 (2000); Gbenou, J. et al.: Mol. Biol. Rep., 40, 1127 (2013);
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