Chemical Name:2’,3-(Boc-amino) 3’’-(Boc-methylamino) N-Boc Des(2-hydroxyethyl) Plazomicin
Synonyms:O-6-Amino-2,3,4,6-tetradeoxy-2-[[(1,1-dimethylethoxy)carbonyl]amino]-α-D-glycero-hex-4-enopyranosyl-(1→4)-O-[3-deoxy-3-[[(1,1-dimethylethoxy)carbonyl]methylamino]-4-C-methyl-β-L-arabinopyranosyl-(1→6)]-2-deoxy-N3-[(1,1-dimethylethoxy)carbonyl]-N1-[(2S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-1-oxobutyl]-D-streptamine
CAS Number:1154758-63-0
Molecular Formula:C₄₃H₇₆N₆O₁₇
Molecular Weight:949.09
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites; Antibotics;
Applications:2’,3-(Boc-amino) 3’’-(Boc-methylamino) N-Boc Des(2-hydroxyethyl) Plazomicin is an intermediate in the synthesis of Plazomicin Sulfate (P579505), the acidic salt of Plazomicin (P579500). Plazomicin is a neoglycoside antibiotic with activity against a broad range of Gram-positive and Gram-negive pathogens. Plazomicin showed potent in vitro activity against multidrug-resistant Klebsiella pneumoniae and Escherichia coli.
References:Endimiani, A. et al.: Antimicrob. Agents Chemother., 53, 4504 (2009); Landman, D. et al.: J. Antimicrob. Chemother., 65, 2123 (2010); Landman, D. et al.: J. Antimicrob. Chemother., 66, 332 (2011);
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