Chemical Name:1,3-bis((1r,4R)-4-(2-(4-(2,3-Dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)urea
Synonyms:Cariprazine Impurity
Molecular Formula:C₃₇H₅₂Cl₄N₆O
Molecular Weight:738.66
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:1,3-bis((1r,4R)-4-(2-(4-(2,3-Dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)urea, is an impurity of Cariprazine (C183490), an orally active D2/D3 dopamine receptor antagonist (1,2,3). Cariprazine is an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression.
References:Gruender, G.: Curr. Opin. Invest. Drugs, 11, 823 (2010); Seneca, N. et al.: Psychopharmacology, 218, 579 (2011); Kiss, B. et al.: J. Pharmacol. Exp. Therap., 333, 328 (2010);
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