Chemical Name:10-epi-Docetaxel
Synonyms:10(S)-Docetaxel
Molecular Formula:C₄₃H₅₃NO₁₄
Molecular Weight:807.88
Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites; Extracted;
Applications:(2aR,4S,4aS,6S,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Benzoate is a synthetic analogue of Paclitaxel (P132500), an antineoplastic of clinical interest for its activity in inhibiting microtubule disassembly and potency to treat lung, ovarian, breast cancer, and advanced forms of Kaposi’s sarcoma.
References:Gueritte-Voegelein, F., et. al.: J. Med. Chem., 34, 992 (1991)Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984);Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984);Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995);Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002);Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004)
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