Chemical Name:1-(2,4-Dichlorobenzoyl)-1H-benzotriazole
Synonyms:1H-Benzotriazol-1-yl(2,4-dichlorophenyl)-methanone; ITSA-1;
CAS Number:200626-61-5
Molecular Formula:C₁₃H₇Cl₂N₃O
Appearance:White to Off-White Solid
Melting Point:119-121°C
Molecular Weight:292.12
Storage:4°C, Inert atmosphere
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Histone deacetylase (HDAC) inhibitors┬аare able to interrupt cell cycle progression in transformed cell lines and may be explored as new clinical agents in cancer therapy. 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole has been shown to suppress the biological effects induced by the HDAC inhibitor, Trichostatin A (T774710).
References:Koeller, K. M., et al.: Chem. Biol. 10, 397 (2003); Vigushin, D., et al.: Clin. Cancer Res. 7, 971 (2001)
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