The Last One Mile in Drug Development
PRODUCT DESCRIPTION CD4 (clone SK3) is a mouse monoclonal antibody that recognizes the extracellular domain of CD4, a membrane glycoprotein of T lymphocytes. This antibody belongs to the Biotium Choice list of select antibodies that have been validated and optimized in-house for optimal performance. The antibody is available conjugated to CF® Dyes and Astral™ tandem […]
LipidSpot™ dyes rapidly stain lipid droplets in live cells or fixed cells, with no wash step required. Available with green or red/far-red fluorescence. PRODUCT DESCRIPTION LipidSpot™ stains are fluorescent dyes that rapidly stain lipid droplets in live or fixed cells, with no wash step and minimal background. Rapidly and specifically stain lipid droplets Minimal background, […]
Conjugates of α-Bungarotoxin labeled with a selection of our CF® Dyes and other labels. Labeled α-bungarotoxin conjugates can be used for staining nicotinic acetylcholine receptors at neuromuscular junctions in tissue sections. PRODUCT DESCRIPTION Alpha-bungarotoxin is a polypeptide snake toxin that binds to the nicotinic acetylcholine receptor found at the neuromuscular junction with high affinity. Fluorescent […]
PRODUCT DESCRIPTION PathoGreen™ Histofluorescent Stain is an anionic green fluorescent dye (Ex/Em 497/520 nm) functionally similar to Fluoro-Jade® dyes. These dyes stain degenerating neurons and their processes after exposure to a variety of neurotoxic insults in brain sections and cultured neurons. The mechanism of neuronal staining by anionic fluorescent dyes has not been determined. It […]
EvaGreen® dyes are next-generation DNA-binding dyes that are ideal for quantitative real-time PCR (qPCR) and many other applications. Biotium scientists designed the dyes by taking into consideration several essential dye properties relevant to PCR, including PCR inhibition, safety, stability and fluorescence spectra of the dye. The result of our efforts is a dye superior to […]
Protein-protein interactions (PPI) are physical and chemical contacts between two or more protein molecules. As a fundamental aspect of almost all biological processes, any interference of the sophisticated PPI network could result in potential physiological disorder or disease. Although some PPI networks have been well-established for their roles in tumor development and therefore have been […]
DNA-encoded library (DEL) technology represents a revolutionary method in drug discovery. Unlike conventional approaches, DEL enables unparalleled exploration of chemical space, leading to the rapid identification of novel potent compounds. Although the importance of DEL screening in hit discovery has been well recognized, the power of DEL technology in compound optimization has only been appreciated […]
Although many covalent drugs were serendipitously discovered historically, covalent inhibitors were in general discouraged due to the concerns over their interference with biological assays and potential lack of selectivity. Over the past decades, rational design of covalent inhibitors has gained traction and garnered increased interest, particularly due to their stronger potency, prolonged target engagement, increased […]
The advancement of DNA Encoded Library (DEL) technology has been significant in recent decades. Beyond its conventional role in small molecule drug discovery, its integration into emerging fields has begun to garner increased interest. This can be attributed to its large chemical space, abundant Structure-Signal Relationship (SSR) data, and inherent DNA conjugation properties. In this […]
Vernalis (R&D) Limited (“Vernalis”), a wholly owned subsidiary of HitGen Inc., and C4X Discovery (“C4XD”) are pleased to announce a collaboration to identify modulators of an undisclosed high-value target involved in inflammatory disease. Within the collaboration, Vernalis will use its state-of-the-art protein science and Hit ID platforms to produce the target protein and to identify […]
