The Last One Mile in Drug Development
At present, four types of lipids have been used as pro-moieties in small molecule lipidic pro-drugs, they are: Fatty Acids (FAs): Lipids enable the free carboxylic acid of the fatty acids to easily conjugate with the free hydroxyl or amine functional groups of other molecules. Such fatty acids are similar to the lipids in biological lipid membranes. In […]
Lipids have a wide range of applications in therapeutics for many years. Recently, lipid nanoparticles have been used for the delivery of mRNA which can resist SARS-COVID-2 virus, and they have also been applied as the delivery carriers of CRISPR/Cas-9 gene-editing technologies. Lipodomics recognize and quantify the level of biological lipids using lipid standards. The […]
Over the past few years, the researchers have been devoting themselves to the new methods to deliver the drugs to the cells and tissues in need with minimum side effects to healthy cells. DSPE-RGD, a liposome-based material that has been modified to contain the RGD peptide sequence, is one of the most promising biomaterials in […]
Messenger RNA (mRNA), a leading edge in current chemical research, plays a key role in recent vaccine development. Previously, the delivery of mRNA through lipid nanoparticles (LNPs) will lead to the accumulation of LNPs in the liver which further limit their access to other organs. Researchers found the targeting LNPs have the ability to deliver […]
In recent years, the research on lipids has become a popular realm to understand various diseases, including cancers, among which Renal Cell Carcinoma (RCC), a kind of common kidney cancers, has attracted significant attention. In order to unravel the intricate relationship between lipids and the development and progress of RCC, researchers explore the lipidome of […]
In recent years, an innovative technique of delivering mRNA to the neural retina has been found for the treatment of inherited retinal degenerations and blindness. Using the peptide-guided lipid nanoparticles (LNPs), scientists have successfully locked on photoreceptor cells in the eyes and achieved the targeted delivery of mRNA to a variety of cell types in […]
As a promising therapeutic reagents delivery method, lipid nanoparticles (LNPs) has brought about a great impact in the pharmaceutical filed. LNPs offer a platform for precise drug delivery and they can be applied in medicine, medical imaging, cosmetics, nutrition, agriculture and other various fields. LNPs are capable of effectively encapsulating and transporting therapeutic payloads, for instance, they can […]
