The Last One Mile in Drug Development
Systemic antibiotic therapy is the major therapeutic method for acute bacterial rhinosinusitis (ABRS). However, this kind of therapy often gives rise to the side effects, such as dizziness, diarrhea and drug resistance. In order to avoid the side effects and achieve sustained release of drugs, researchers developed a new polyethylene glycol hydrogel (PEG-H) treatment model. […]
In orthopaedic surgeries, the implant-associated infections are extremely critical as they may hinder bone healing, resulting in implant failure and even osteomyelitis. Used for local delivery of antibiotics at surgical sites, drug-eluting implants are considered to be a promising tool in infection prevention. The antibiotic vancomycin was encapsulated in a polyethylene glycol (PEG)-based hydrogel film which […]
Definition PEI (Polyetherimide) is an amorphous amber-to-transparent engineering thermoplastic. The molecular formula of PEI is C37H24O6N2. Owing to its high temperature resistance and tensile strength, dimensional stability, excellent flame resistance and low smoke emission, PEI has been an ideal material used in the automotive, electrical, medical and other industrial fields. It is also a promising […]
The development of nanoscale delivery vehicles based on polymeric micelles has attracted attention in the diagnostic and therapeotic applications in biomedicine. To construct a micellar magnetic resonance imaging (MRI) contrast agent (CA) with biocompatibility and targeting specificity, researchers synthesized two types of amphiphilic diblock polymers, mPEG-PG(DOTA(Gd))-b-PCL and FA-PEG-b-PCL, to form mixed micelles by coassembly. Consisting of poly(caprolactone) […]
Found in the freshwater microalga Ochromonas danica, the amphiphilic chlorosulfolipids are very unique due to their high levels of chlorination and sulfation. The major chlorosulfolipid found in O. danica is danicalipin A which contains six chlorination and two sulfates with certain stereochemistry on a linear 22-carbon chain. It is difficult to purify danicalipin A from natural resources, so there […]
As there are cell-suicide weapons existing in mitochondria, the mitochondria-mediated apoptosis pathway is an effective option for cancer therapy. However, the efficacy of this kind of chemotherapy are greatly reduced due to the apoptosis evading of cancer cells allowed by the anti-apoptotic proteins that are over-expressed in the mitochondria of many malignant tumors, such as […]
Normally, the structural analysis of complex lipids relies on tandem mass spectrometry (MS/MS) or the activation methods based on collision, such as collision-induced dissociation (CID) and higher-energy collisional dissociation (HCD). In the previous, these methods were not been used to explore the subtle characteristics of glycerophospholipids, such as sn-stereochemistry and unsaturation elements, including cyclopropane modification […]
Definition PAMAM (Poly(amidoamine)), a class of dendrimer with spherical shape composed of repeatedly branched subunits of amide and amine functionality, is characterized by an internal molecular structure of tree-like branches, with each outward layer containing exponentially more branching points. PAMAM has good molecular uniformity, narrow distribution of molecular weight, defined size and shape characteristics, as well as a multifunctional […]
Due to the large surface area and excellent mechanical flexibility, Photoluminescent (PL) graphene quantum dots (GQDs) with fascinating optical and electronic properties have promising applications in biomedical engineering. In order to enhance the therapeutic efficiency, the research team proposed a multifunctional nanocomposite of poly(l-lactide) (PLA) and polyethylene glycol (PEG)-grafted GQDs (f-GQDs) used for the analysis of intracellular […]
The design of nanoscale drug delivery systems used for the targeted co-delivery of multiple therapeutic drugs still remains a challenge. However, researchers prepared mitomycin C (MMC) and methotrexate (MTX) loaded DSPE-PEG micelles (MTX-M-MMC) by self-assembly using the dialysis technique, and the MMC-soybean phosphatidylcholine complex was encapsulated in the MTX-functionalized DSPE-PEG micelles. The experiment suggested that MTX-M-MMC coordinate the early […]
