Drug Delivery

Catalogue Number:B200000Chemical Name:(1R,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl EsterCAS Number:629652-44-4Molecular Formula:C₂₂H₁₉ClN₂O₅Appearance:Light Beige SolidMelting Point:>190°C (dec.)Molecular Weight:426.85Storage:4°CSolubility:DMSO, Methanol (Sparingly)Category:Standards; Chiral Molecules; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;Applications:Tadalafil (T004500) derivative.References:Beghyn, T. et al.: Bioorgan. Med. Chem. Lett. 17, 789(2007)To ensure the stability of our products, the efficient express delivery service will be used. We also guarantee that the products […]

Catalogue Number:B199995Chemical Name:(1R,​3R)​-1-​(1,​3-​Benzodioxol-​5-​yl)​-​2,​3,​4,​9-​tetrahydro-1H-​pyrido[3,​4-​b]​indole-​3-​carboxamideSynonyms:Tadalafil Amide Impurity:CAS Number:1370438-57-5Molecular Formula:C₁₉H₁₇N₃O₃Molecular Weight:335.36Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;Applications:(1R,​3R)​-1-​(1,​3-​Benzodioxol-​5-​yl)​-​2,​3,​4,​9-​tetrahydro-1H-​pyrido[3,​4-​b]​indole-​3-​carboxamide is an analogue of Tadalafil (T004500), which is a human PDE5 inhibitor. (1R,​3R)​-1-​(1,​3-​Benzodioxol-​5-​yl)​-​2,​3,​4,​9-​tetrahydro-1H-​pyrido[3,​4-​b]​indole-​3-​carboxamide is a weak inhibitor of TbrPDEB1.References:Ochiana, S.O., et al.: Bioorg. Med. Chem. Lett., 22, 2582 (2012)To ensure the stability of our products, the efficient express delivery service will be used. We […]

Catalogue Number:B199990Chemical Name:(1R,​3R)​-1-​(1,​3-​Benzodioxol-​5-​yl)​-​2,​3,​4,​9-​tetrahydro-1H-pyrido[3,​4-​b]​indole-​3-​carboxylic Acid HydrochlorideSynonyms:(1R,3R)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Monohydrochloride; Tadalafil Acid Impurity:CAS Number:474668-76-3Alternate CAS #Free acid: 406938-39-4Molecular Formula:C₁₉H₁₆N₂O₄ . HClAppearance:Light Yellow SolidMelting Point:>200°C (dec.)Molecular Weight:372.8Storage:4°CSolubility:DMSO (Slightly), Methanol (Slightly)Category:Standards; Chiral Molecules;Applications:(1R,​3R)​-1-​(1,​3-​Benzodioxol-​5-​yl)​-​2,​3,​4,​9-​tetrahydro-1H-pyrido[3,​4-​b]​indole-​3-​carboxylic Acid Hydrochloride is an impurity of Tadalafil (T004500) and is a b-​carboline derivative. (1R,​3R)​-1-​(1,​3-​Benzodioxol-​5-​yl)​-​2,​3,​4,​9-​tetrahydro-1H-pyrido[3,​4-​b]​indole-​3-​carboxylic Acid Hydrochloride can be used to produce Tadalafil.References:Lek Pharmaceuticals d.d., Slovenia: Eur. Pat. […]

Catalogue Number:B199420Chemical Name:N-((1-(2-(3-(tert-Butyl)ureido)ethyl)-4-(hydroxymethyl)piperidin-4-yl)methyl)-3,5-dichlorobenzamideSynonyms:3,​5-​Dichloro-​N-​[[1-​[2-​[[[(1,​1-​dimethylethyl)​amino]​carbonyl]​amino]​ethyl]​-​4-​(hydroxymethyl)​-​4-​piperidinyl]​methyl]​benzamideCAS Number:1416984-93-4Molecular Formula:C₂₁H₃₂Cl₂N₄O₃Molecular Weight:459.41Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;Applications:N-((1-(2-(3-(tert-Butyl)ureido)ethyl)-4-(hydroxymethyl)piperidin-4-yl)methyl)-3,5-dichlorobenzamide is discovered as a potential peripheral T-type calcium channel inhibitor, its hERG and CYP 2D6 inhibition, microsomal stability, and pharmacokinetics and heart rate reduction in dogs.References:Giordanetto, F., et al.:Bioorg. Med. Chem. Lett. 23, 119 (2013)To ensure the stability of our products, the […]

Catalogue Number:B199183Chemical Name:3-Bromo-6-chloro-2-nitropyridineCAS Number:1805409-46-4Molecular Formula:C₅H₂BrClN₂O₂Molecular Weight:237.44Category:Building Blocks; Miscellaneous;Applications:3-Bromo-6-chloro-2-nitropyridine is a useful research chemical compound for organic synthesis and other chemical processes.To ensure the stability of our products, the efficient express delivery service will be used. We also guarantee that the products will be shipped in the box with layers of tapes to protect them against […]

Catalogue Number:B199180Chemical Name:3-Bromo-6-fluoro-2-nitropyridineCAS Number:1805508-51-3Molecular Formula:C₅H₂BrFN₂O₂Molecular Weight:220.98Category:Building Blocks; Miscellaneous;Applications:3-Bromo-6-fluoro-2-nitropyridine with (CAS # 1805508-51-3) is a useful research chemical compound for organic synthesis and other chemical processes.To ensure the stability of our products, the efficient express delivery service will be used. We also guarantee that the products will be shipped in the box with layers of tapes […]

Catalogue Number:B199005Chemical Name:N-Desmethyl-N-cyclopentyl cis-ent-TadalafilCAS Number:171488-19-0Molecular Formula:C₂₆H₂₅N₃O₄Molecular Weight:443.49Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;Applications:N-Desmethyl-N-cyclopentyl cis-ent-Tadalafil is a derivative of Tadalafil (T004500). Tadalafil is a phosphodiesterase type-5 inhibitor that is used to treat erectile dysfunction.References:Galie, N., et al.: Circulation, 119, 2894 (2009); Porst, H., et al.: Urology, 62, 121 (2003)To ensure the stability of our products, the efficient express delivery […]

Catalogue Number:B199000Chemical Name:N-Desmethyl-N-cyclopentyl TadalafilSynonyms:(6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2-cyclopentyl-2,3,6,7,12,12a-hexahydropyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione; (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2-cyclopentyl-2,3,6,7,12,12a-hexahydropyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dioneCAS Number:171596-32-0Molecular Formula:C₂₆H₂₅N₃O₄Appearance:Off-White to Pale Yellow SolidMelting Point:>168°C (dec.)Molecular Weight:443.49Storage:4°CSolubility:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;Applications:N-Desmethyl-N-cyclopentyl Tadalafil is used as a reagent to synthesize tetracyclic cGMP-specific phosphodiesterase inhibitors, compounds that have potential to treat cardiovascular disorders and erectile dysfunction.References:Daugan, A. & Gellibert, F. Tetracyclic cGMP-specific Phosphodiesterase Inhibitors and Their […]

Catalogue Number:B198960Chemical Name:(3R)-3-[[2-(1,3-Benzodioxol-5-ylcarbonyl)-1H-indol-3-yl]methyl]-1-methyl-2,5-piperazinedioneCAS Number:1220393-12-3Molecular Formula:C₂₂H₁₉N₃O₅Appearance:Pale Yellow SolidMelting Point:>221°C (dec.)Molecular Weight:405.4Storage:-20°CSolubility:Chloroform (Slightly), DMSO (Slightly)Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;Applications:(3R)-3-[[2-(1,3-Benzodioxol-5-ylcarbonyl)-1H-indol-3-yl]methyl]-1-methyl-2,5-piperazinedione (cas# 1220393-12-3) is a compound useful in organic synthesis.To ensure the stability of our products, the efficient express delivery service will be used. We also guarantee that the products will be shipped in the box […]

Catalogue Number:B198855Chemical Name:11-(1,3-Benzodioxol-5-yl)-5,17-dihydroxy-17-(1-propynyl)-estr-9-en-3-one Cyclic 1,2-Ethanediyl AcetalCAS Number:189035-19-6Molecular Formula:C₃₀H₃₆O₆Molecular Weight:492.6Category:Standards; Steroids;Applications:11-(1,3-Benzodioxol-5-yl)-5,17-dihydroxy-17-(1-propynyl)-estr-9-en-3-one Cyclic 1,2-Ethanediyl Acetal is an intermediate used in the synthesis of (11β,17β)-11-(1,3-Benzodioxol-5-yl)-17-hydroxy-17-(1-propyn-1-yl)estra-4,9-dien-3-one (B198850), which is a glucocorticoid receptor (GR) antagonists.References:Verdouw, P. M., et al.: Pharmacol. Biochem. Behav., 154, 11-19 (2017); Reynolds, A. R., et al.: Drug Alcohol. Dep., 154, 100-104 (2015)To ensure the stability of […]