Drug Delivery

Catalogue Number:B398962Chemical Name:1,4’-Bipiperidine-2,2,3,3,4,4,5,5,6,6-d10Synonyms:4-(1-Piperidino)piperidine-d10;CAS Number:718613-20-8Alternate CAS #unlabelled: 4897-50-1Molecular Formula:C₁₀H₁₀D₁₀N₂Appearance:Pale Yellow SolidMelting Point:63-66°CMolecular Weight:178.34Storage:4°CSolubility:Chloroform (Slightly), Methanol (Slightly)Category:Building Blocks; Isotopic Labeled Analogues; Miscellaneous;Applications:Isotope labelled 1,4’-Bipiperidine is used in the synthesis of selective sphingosine kinase 1 inhibitors used as a therapeutic agent for proliferative diseases. Also used in the synthesis of calcitonin gene-related (CGRP) receptor antagonists.References:Baek, D. et al.: […]

Catalogue Number:B398960Chemical Name:1,4’-BipiperidineSynonyms:4-(1-Piperidino)piperidine; 1-(4-Piperidyl)piperidine; 1-(Piperidin-4-yl)piperidine; 4-(1-Piperidinyl)piperidine; 4-Piperidinopiperidine; [1,4′]BipiperidinylCAS Number:4897-50-1Molecular Formula:C₁₀H₂₀N₂Appearance:Off-White to Pale Red SolidMelting Point:58-63°CMolecular Weight:168.28Storage:20°C, Inert atmosphereSolubility:Chloroform (Slightly), Methanol (Slightly)Category:Building Blocks; Miscellaneous;Applications:1,4’-Bipiperidine is used in the synthesis of selective sphingosine kinase 1 inhibitors used as a therapeutic agent for proliferative diseases. Also used in the synthesis of calcitonin gene-related (CGRP) receptor antagonists.References:Baek, D. et […]

Catalogue Number:B398720Chemical Name:4-((3R,5S)-5-([1,1′-Biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoic AcidSynonyms:Valsartan Impurity:CAS Number:2216746-87-9Molecular Formula:C₂₂H₂₃NO₄Appearance:White to Off-White SolidMelting Point:>48°C (dec.)Molecular Weight:365.42Storage:4°C, Inert atmosphereSolubility:Chloroform (Slightly), Ethanol (Slightly, Sonicated)Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;Applications:4-((3R,5S)-5-([1,1′-Biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoic Acid is an impurity compound of Valsartan (V095750). Valsartan is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.References:Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. […]

Catalogue Number:B398710Chemical Name:(2R,4S)-5-([1,1′-Biphenyl]-4-yl)-4-(4-ethoxy-4-oxobutanamido)-2-methylpentanoic AcidSynonyms:Valsartan Impurity:CAS Number:149709-49-9Molecular Formula:C₂₄H₂₉NO₅Molecular Weight:411.49Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;Applications:(2R,4S)-5-([1,1′-Biphenyl]-4-yl)-4-(4-ethoxy-4-oxobutanamido)-2-methylpentanoic Acid is an impurity compound of Valsartan (V095750). Valsartan is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.References:Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)To ensure the stability of our products, the […]

Catalogue Number:B398500Chemical Name:3-(4-Biphenylyl)-1,2,3,4-tetrahydro-1-naphtholSynonyms:3-p-Biphenylyl-1-tetralinol; 3-[1,1′-Biphenyl]-4-yl-1,2,3,4-tetrahydro-1-naphthalenolCAS Number:56181-66-9Molecular Formula:C₂₂H₂₀OAppearance:White to Pale Beige SolidMelting Point:>142°C (dec.)Molecular Weight:300.39Storage:-20°CSolubility:DMSO (Slightly), Methanol (Slightly, Heated)Category:Building Blocks; Miscellaneous;Applications:3-(4-Biphenylyl)-1,2,3,4-tetrahydro-1-naphthol is a useful synthetic intermediate in the synthesis of Difenacoum (D445350)References:Van Heerden, P.S., et al.: J. Chem. Soc., Perkin Trans. 1., no vol., 1141 (1997); Hadler, M.R. et al.: J. Hygiene, 74, 441 (1975); Rehman, A.B. […]

Catalogue Number:B398190Chemical Name:Benzeneseleninic Acid AnhydrideCAS Number:17697-12-0Molecular Formula:C12H10O3Se2Molecular Weight:360.13Category:Research Tools; Molecular Biology;Applications:Benzeneseleninic Acid Anhydride can be useful in the study of oxidative cleavage proposed in biogenesis of transtaganolides/basiliolides with pyran-2-one aromaticity-mediated regioselective control and biogenetic implications.References:Alvarez, J. M., et al.: Eur. J. Org. Chem., 2020, 1673 (2020)To ensure the stability of our products, the efficient express […]

Catalogue Number:B398175Chemical Name:(2R,4S)-5-([1,1′-Biphenyl]-4-yl)-4-amino-2-methylpentanoic Acid HydrochlorideSynonyms:(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic acid hydrochloride; (2R,4S)-4-Amino-5-([1,1′-biphenyl]-4-yl)-2-methyl-pentanoic acid hydrochlorideCAS Number:1038924-71-8Alternate CAS #1039307-95-3Molecular Formula:C₁₈H₂₁NO₂ • HClMolecular Weight:283.36 + (36.46)Category:Building Blocks; Miscellaneous;Applications:(2R,4S)-5-([1,1′-Biphenyl]-4-yl)-4-amino-2-methylpentanoic Acid Hydrochloride, is a building block used in various chemical synthesis, such as in the synthesis of Sacubitri (S080900), an antihypertensive drug.References:McMurray, J., et al.: N. Eng. J. Med., 371 (2014)To ensure the stability […]

Catalogue Number:B398165Chemical Name:(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid Ethyl EsterSynonyms:(αR,γS)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl-[1,1′-Biphenyl]-4-pentanoic Acid Ethyl EsterCAS Number:149709-60-4Molecular Formula:C₂₅H₃₃NO₄Molecular Weight:411.53Category:Building Blocks; Miscellaneous;Applications:(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid Ethyl Ester, is a building block used in various chemical synthesis, such as in the synthesis of Sacubitri (S080900), an antihypertensive drug.References:McMurray, J., et al.: N. Eng. J. Med., 371 (2014)To ensure the stability of our products, the efficient express […]

Catalogue Number:B398160Chemical Name:(2E,4S)-5-[1,1′-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic AcidCAS Number:1015037-46-3Molecular Formula:C₂₃H₂₇NO₄Molecular Weight:381.46Category:Building Blocks; Miscellaneous;Applications:(2E,4S)-5-[1,1′-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic Acid was used in the study to process for preparation of biaryl-substituted 4-aminobutyric acids by hydrogenation of the corresponding alkenoates.References:Hook, D., et al.: PCT Int. Appl. (2008), WO 2008031567 A1 20080320.To ensure the stability of our products, the efficient express delivery service will be used. We […]

Catalogue Number:B398155Chemical Name:(2S,2’S)-2,2′-([1,1′-Biphenyl]-4,4′-diyldi-1H-imidazole-5,2-diyl)bis-1-pyrrolidinecarboxylic Acid 1,1′-Bis(1,1-dimethylethyl) EsterCAS Number:1007882-23-6Molecular Formula:C₃₆H₄₄N₆O₄Appearance:White to Off-White SolidMelting Point:213°CMolecular Weight:624.77Storage:4°CSolubility:DMSO (Slightly), Methanol (Slightly)Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites; Anti-virals/Anti-retrovirals;Applications:(2S,2’S)-2,2′-([1,1′-Biphenyl]-4,4′-diyldi-1H-imidazole-5,2-diyl)bis-1-pyrrolidinecarboxylic Acid 1,1′-Bis(1,1-dimethylethyl) Ester is an antiviral agent and Daclatasvir (D101500) intermediate. Daclatasvir inhibits the HCV protein NS5A and thus can be used as a drug candidate for the treatment of hepatitis C (HCV).References:Gao, M., et […]