The researchers from the Perelman School of Medicine of the University of Pennsylvania published a paper entitled “CAR T cells produced in vivo to treat cardiac injury” on the “Science” on Jan 6th, 2022. The study demonstrated that the injection of mRNA LNP is capable of creating CAR-T cells in vivo directly, which can attack specific targets through a single injection of mRNA to successfully […]

Antibody-drug Conjugates (ADCs), one of the fast-developing anticancer drugs, are the conjugation of monoclonal antibodies and small-molecule cytotoxic drugs. ADCs are well known for both the targeting ability with high specificity of antibody drugs and the powerful killing efficiency of traditional small-molecule cytotoxic drugs. They can be identified by the antigen specificity of the monoclonal antibodies and the surface of tumor […]

Neurons are the fundamental unit of the brain and central nervous system, they are responsible for the reception of sensory information and the delivery of the motion command to our muscles. These cells interact with each other to form a network of information delivery, and the key components of network are synaptic junctions. The synaptic junction is […]

siRNAs are small double-stranded RNAs which can control the expression of specific genes, and the process is done by degrading mRNA after transcription. siRNAs are perfect therapeutic agents for the disease-causing gene-silencing expression due to their high degree of specificity. In addition, as they are hydrophilic and with large size, there are several problems that should be overcome […]

As we all know, cholesterol with a high level can result in heart disease and stroke. However, at the same time, cholesterol is necessary for healthy cell building in our bodies, and it can be used for therapeutics to save our lives. Existing in biological system, cholesterol is a membrane constituent that is capable of modulating membrane fluidity, […]

Antibiotic resistance is a serious threat which could reduce the body sensitivity to the drugs. The Centers for Disease and Control (CDC) in  the United States reported and listed several antibiotic-resistant pathogens which are considered threats, such as Carbapenem-resistant Acinetobacter, Candida aureus, Clostridioides difficile, Drug-resistant Neisseria gonorrhoeae and Methicillin-resistant Staphylococcus aureus (MRSA), among which MRSA […]

As is known to all, ceramides, a kind of lipids found in skin cells, are an important part of the stratum corneum (SC). As the outermost layer of the skin, the stratum corneum (SC) is the bond to connect our body to the outside. Acting as a barrier, the SC prevent the unnecessary materials from […]

At present, four types of lipids have been used as pro-moieties in small molecule lipidic pro-drugs, they are: Fatty Acids (FAs): Lipids enable the free carboxylic acid of the fatty acids to easily conjugate with the free hydroxyl or amine functional groups of other molecules. Such fatty acids are similar to the lipids in biological lipid membranes. In […]

Lipids have a wide range of applications in therapeutics for many years. Recently, lipid nanoparticles have been used for the delivery of mRNA which can resist SARS-COVID-2 virus, and they have also been applied as the delivery carriers of CRISPR/Cas-9 gene-editing technologies. Lipodomics recognize and quantify the level of biological lipids using lipid standards. The […]

Over the past few years, the researchers have been devoting themselves to the new methods to deliver the drugs to the cells and tissues in need with minimum side effects to healthy cells. DSPE-RGD, a liposome-based material that has been modified to contain the RGD peptide sequence, is one of the most promising biomaterials in […]