The compounds conjugated with PEG (functional PEGs) have many advantages. Ever since its discovery, PEGylation is of increasing interest in biological and medical studies owing to their solubility in water, excellent biocompatibility and non-immunogenicity. The US-based chemical supplier Alfa Chemistry announces in a recent statement that it starts to provide functional PEGs for scientific research. Polyethylene glycol […]
A New Polyethylene Glycol Hydrogel (PEG-H) Model for Acute Bacterial Rhinosinusitis Treatment
Systemic antibiotic therapy is the major therapeutic method for acute bacterial rhinosinusitis (ABRS). However, this kind of therapy often gives rise to the side effects, such as dizziness, diarrhea and drug resistance. In order to avoid the side effects and achieve sustained release of drugs, researchers developed a new polyethylene glycol hydrogel (PEG-H) treatment model. […]
The Prevention of Bone Infections By Immobilizing Antibiotic-Loaded Polymeric Coatings on Orthopaedic Implants
In orthopaedic surgeries, the implant-associated infections are extremely critical as they may hinder bone healing, resulting in implant failure and even osteomyelitis. Used for local delivery of antibiotics at surgical sites, drug-eluting implants are considered to be a promising tool in infection prevention. The antibiotic vancomycin was encapsulated in a polyethylene glycol (PEG)-based hydrogel film which […]
The Potential of the Poly(glycerol) Used for Mixed Micelles for Tumor-Targeted Imaging
The development of nanoscale delivery vehicles based on polymeric micelles has attracted attention in the diagnostic and therapeotic applications in biomedicine. To construct a micellar magnetic resonance imaging (MRI) contrast agent (CA) with biocompatibility and targeting specificity, researchers synthesized two types of amphiphilic diblock polymers, mPEG-PG(DOTA(Gd))-b-PCL and FA-PEG-b-PCL, to form mixed micelles by coassembly. Consisting of poly(caprolactone) […]
What Effects the Chlorosulfolipids in Ochromonas Danica Have on Lipid Bilayers
Found in the freshwater microalga Ochromonas danica, the amphiphilic chlorosulfolipids are very unique due to their high levels of chlorination and sulfation. The major chlorosulfolipid found in O. danica is danicalipin A which contains six chlorination and two sulfates with certain stereochemistry on a linear 22-carbon chain. It is difficult to purify danicalipin A from natural resources, so there […]
The Activation of Mitochondria Apoptosis Pathway for Cancer Therapy by Co-develiery of siRNA and Lonidamine
As there are cell-suicide weapons existing in mitochondria, the mitochondria-mediated apoptosis pathway is an effective option for cancer therapy. However, the efficacy of this kind of chemotherapy are greatly reduced due to the apoptosis evading of cancer cells allowed by the anti-apoptotic proteins that are over-expressed in the mitochondria of many malignant tumors, such as […]
The Exploration of Cyclopropane Modifications by Ultraviolet Photodissociation Mass Spectrometry
Normally, the structural analysis of complex lipids relies on tandem mass spectrometry (MS/MS) or the activation methods based on collision, such as collision-induced dissociation (CID) and higher-energy collisional dissociation (HCD). In the previous, these methods were not been used to explore the subtle characteristics of glycerophospholipids, such as sn-stereochemistry and unsaturation elements, including cyclopropane modification […]
The Multifunctional Nanocomposite of Poly(l-Lactide) and Polyethylene Glycol-Grafted GQDs for Enhanced Therapeutics and Molecule Analysis
Due to the large surface area and excellent mechanical flexibility, Photoluminescent (PL) graphene quantum dots (GQDs) with fascinating optical and electronic properties have promising applications in biomedical engineering. In order to enhance the therapeutic efficiency, the research team proposed a multifunctional nanocomposite of poly(l-lactide) (PLA) and polyethylene glycol (PEG)-grafted GQDs (f-GQDs) used for the analysis of intracellular […]
Mitomycin C and Methotrexate Loaded DSPE-PEG Micelles: A Key Factor for Nanoscale Drug Delivery System
The design of nanoscale drug delivery systems used for the targeted co-delivery of multiple therapeutic drugs still remains a challenge. However, researchers prepared mitomycin C (MMC) and methotrexate (MTX) loaded DSPE-PEG micelles (MTX-M-MMC) by self-assembly using the dialysis technique, and the MMC-soybean phosphatidylcholine complex was encapsulated in the MTX-functionalized DSPE-PEG micelles. The experiment suggested that MTX-M-MMC coordinate the early […]
The Roles the Diverse Phosphatidic Acid Species Play on Exocytoses
Phosphatidic Acid (PA) has aroused people’s interests due to its role in diverse key biological functions, including its being an intermediate in the synthesis of all membrane glycerophospholipids, a participant of membrane biogenesis, a necessary signaling molecule in cell proliferation and cytoskeletal rearrangement, as well as a participant in endocrine, neuroendocrine exocytosis and synaptic neurotransmission. Mammals can have more than […]