Catalogue Number:D232935
Chemical Name:2-Deoxy-D-erythro-pentopyranosyl Chloride Bis(4-methylbenzoate)(Decitabine Impurity)(Mixture of α/β isomers)
CAS Number:20535-28-8
Alternate CAS #
α-Isomer: 20535-28-8/ β-Isomer: 516511-18-5
Molecular Formula:C₂₁H₂₁ClO₅
Molecular Weight:388.84
Category:Research Tools;
Applications:2-Deoxy-D-erythro-pentopyranosyl chloride bis(4-methylbenzoate) is an impurity of Decitabine (α-isomer: D226730), a DNA hypomethylating agent that is used to treat various forms of cancer, such as myelogeneous leukemia and metastatic lung cancerBy inhibiting DNA methyltransferase, Decitabine silences the tumour suppressor genes and, consequently, “normalizing” gene expression in cancerous cells.
References:Aribi, A., et al.: Cancer, 109, 713 (2007); Issa, J., et al.: Blood, 103, 1635 (2004); Kantarjian , H., et al.: Cancer, 98, 522 (2003); Momparler, R., et al.: Anti-Cancer Drug., 8, 358 (1997); Plimack, E., et al.: Leukemia Lymphoma, 48, 1472 (2007)
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