N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[2-((1-Oxyl-2,2,5,5-tetramethylpyrroline-3-yl)carbamido)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine

Chemical Name:N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[2-((1-Oxyl-2,2,5,5-tetramethylpyrroline-3-yl)carbamido)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine
Synonyms:Demethylsulfonyl Lapatinib 1-Oxyl-2,2,5,5-tetramethyl-Æ3-pyrroline deriv;
Molecular Formula:C₃₇H₃₇ClFN₆O₄
Molecular Weight:684.18
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[2-((1-Oxyl-2,2,5,5-tetramethylpyrroline-3-yl)carbamido)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine is an analog of Lapatinib Ditosylate (L175800) which acts as a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.
References:Kim, T.E., et al.: Drugs, 6, 886 (2003), Wood, E.R., et al.: Cancer Res., 64, 6652 (2004), Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005),
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