(2S,3S)-3-[[[(1S)-1-[[(4-Azidobutyl)amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic Acid Ethyl Ester-d8

Chemical Name:(2S,3S)-3-[[[(1S)-1-[[(4-Azidobutyl)amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic Acid Ethyl Ester-d8
Synonyms:N3Le-d8
Molecular Formula:C₁₆H₁₉D₈N₅O₅
Molecular Weight:377.47
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Labelled N3Le is a derivative of E-64 an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases.
References:Song, J. et al.: Bioorg. Med. Chem. Lett., 23, 2801 (2013); Song, J. et al.: ACS. Med. Chem. Lett., 3, 450 (2012);
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