Catalogue Number:C262600
Chemical Name:C6 Ceramide
Synonyms:N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]hexanamide;
CAS Number:124753-97-5
Molecular Formula:C₂₄H₄₇NO₃
Appearance:White to Off-White Solid
Melting Point:76 – 77°C
Molecular Weight:397.63
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors; Lipids/Fatty Acids, Glycerol Derivatives;
Applications:A biologically active, cell permeable, but nonphysiologic ceramide analog. It stimulates protein phosphatase 2A at concentrations as low as 10 nM and activiates MAP kinase. It induces apoptosis and inhibits glycoproptein traffic by the secretory pathway.
References:Liu, Z., et al.: J. Neurochem., 106, 2463 (2008), Heakal, Y., et al.: Mol. Cancer Res., 7, 724 (2009), Chen-Quay, S., et al.: J. Pharm. Sci., 98, 606 (2009), Mahdy, A., et al.: Mol. Ther., 17, 430 (2009),
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