Chemical Name:4-(3-Fluoro-4-((2-(methyl-d3-carbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpicolinamide
Alternate CAS #:Unlabelled CAS# N/A
Molecular Formula:C₂₀H₁₅D₃FN₅O₃
Molecular Weight:398.41
Category:Building Blocks; Isotopic Labeled Analogues;
Applications:4-(3-Fluoro-4-((2-(methyl-d3-carbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpicolinamide is the labeled analogue of 4-(3-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpicolinamide (F593180), an impurity of Regorafenib (R143000), which inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent.
References:Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000)
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