3-Imidazo[1,2-a]pyridin-3-yl-4-[1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepin-7-yl]-1H-pyrrole-2,5-dione

Chemical Name:3-Imidazo[1,2-a]pyridin-3-yl-4-[1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepin-7-yl]-1H-pyrrole-2,5-dione
Synonyms:7-(2,5-Dihydro-4-imidazo[1,2-a]pyridin-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepine; LY2090314
CAS Number:603281-60-3
Molecular Formula:C28H26N6O3
Molecular Weight:494.6
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:3-Imidazo[1,2-a]pyridin-3-yl-4-[1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepin-7-yl]-1H-pyrrole-2,5-dione is a newly developed potent and selective biarylmaleimide GSK3 inhibitor which may be effective in lowering plasma glucose in type 2 diabetes.
References:Engler, T.A.. et al.: Bioorg. Med. Chem. Lett., 15, 899 (2005); Engler, T.A., et al.: J. Med. Chem., 47, 3934 (2004); Dessalew, N., et al.: Europ. J. Med. Chem., 42, 1014 (2007);
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