Chemical Name:Ilepatril
Synonyms:(4S,7S,12bR)-7-[[(2S)-2-(Acetylthio)-3-methyl-1-oxobutyl]amino]-1,2,3,4,6,7,8,12b-octahydro-6-oxo-pyrido[2,1-a][2]benzazepine-4-carboxylic Acid; AVE-7688;
CAS Number:473289-62-2
Molecular Formula:C₂₂H₂₈N₂O₅S
Molecular Weight:432.53
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:A dual angiotensin-converting enzyme and neutral endopeptidase inhibitor, for the potential treatment of hypertension and diabetic nephropathy. Ilepatril is currently in phase IIb/III clinical trials for hypertension and phase II trials for diabetic nephropathy.
References:Tabrizchi, R., et al.: Drugs, 63, 2185 (2003), Azizi, M., et al.: Clin. Pharmacol. Ther., 79 49 (2006), Davidson, E., et al.: Diabetes, 56, 355 (2007), Del Colle, S., et al.: J. Cardiovasc. Pharmacol., 50, 487 (2007),
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