Tamoxifen 4-N,N-Dimethyl-2-[4-(phenylmethyl)phenoxy]ethanamine

Chemical Name:Tamoxifen 4-N,N-Dimethyl-2-[4-(phenylmethyl)phenoxy]ethanamine
Synonyms:(E)-2-(4-(1-(4-((4-(2-(Dimethylamino)ethoxy)phenyl)(phenyl)methyl)phenyl)-2-phenylbut-1-en-1-yl)phenoxy)-N,N-dimethylethanamine; 2-(4-(1-(4-((4-(2-(Dimethylamino)ethoxy)phenyl)(phenyl)methyl)phenyl)-2-phenylbut-1-en-1-yl)phenoxy) Tamoxifen
CAS Number:2125703-03-7
Molecular Formula:C₄₃H₄₈N₂O₂
Molecular Weight:624.85
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-(4-(1-(4-((4-(2-(dimethylamino)ethoxy)phenyl)(phenyl)methyl)phenyl)-2-phenylbut-1-en-1-yl)phenoxy) Tamoxifen is an impurity of Tamoxifen whcih is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4.
References:Sutherland, R., et al.: Nature, 267, 434 (1977), Lerner, L., et al.: Cancer Res., 50, 4177 (1990), Love, R., et al.: J. Clin. Oncol., 20 2559 (2002),
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