Chemical Name:Dolutegravir RR Isomer
Synonyms:(4R,12aR)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pPyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
CAS Number:1357289-29-2
Molecular Formula:C₂₀H₁₉F₂N₃O₅
Molecular Weight:419.38
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; Anti-virals/Anti-retrovirals;
Applications:Dolutegravir RR Isomer is an isomer of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
References:Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);
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