Chemical Name:Caspofungin Impurity A Acetate Salt
Synonyms:(3S)-(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithyl-L-seryl-(4R)-4-hydroxy-L-prolyl-(4S)-4-hydroxy-4-(4-hydroxyphenyl)-L-threonyl-(3R)-3-hydroxy-L-ornithyl-3-hydroxy-L-proline Acetate Salt;
Impurity
Caspofungin Impurity
Alternate CAS #:1202167-57-4
Molecular Formula:C₅₁H₈₆N₁₀O₁₅ • x(C ₂H₄O₂)
Appearance:Pale Yellow Solid
Molecular Weight:1079.29 + x(60.05)
Storage:-20°C, Hygroscopic
Solubility:Methanol (Slightly)
Stability
Hygroscopic
Category:Standards; Molecular Biology; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Caspofungin Impurity A, is a metabolite of Caspofungin (C184900), which is an echinocandin that inhibits the synthesis of b (1,3)-D-glucan, an integral component of the fungal cell wall, and thus used as antifungal drug.
References:Sandhu, P. et al.: Antimicrob. Agents Chemorther., 48, 1272 (2004); Bertsche, T. et al.: Pharamaz. Zeit., 148, 34 (2003); Hoang, A.: Am. J. Health-Sys. Pharm., 58, 1206 (2001);
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