Catalogue Number:B411990
Chemical Name:BGP 15
Synonyms:N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide Dihydrochloride;
CAS Number:66611-37-8
Alternate CAS #
Free Form: 66611-38-9
Molecular Formula:C₁₄H₂₂N₄O₂ • 2(HC l)
Appearance:Pale Yellow to Pale Beige Solid
Melting Point:>177°C (dec.)
Molecular Weight:278.35 + (72.92)
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Standards; Enzyme Activators and Inhibitors; Vitamin Derivatives; Vitamin D Derivatives;
Applications:BGP 15 is a calcipotriene-based vitamin D3 analog that inhibits poly(ADP-ribose) polymerasesis (PARP), a class of enzymes that regulate DNA repair and apoptosis (1). BGP 15 is also a cardioprotective agent (2). Also, BPG 15 improves mitochondrial function, protects neurons from dying in vitro and in vivo, and promotes cardiac innervation in vivo.
References:(1) Berkovich, L., et al.: Anticancer Drugs. 21, 609 (2010)
(2) Szabados, E., et al. Biochem Pharmacol. 59, 937 (2000)
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