Catalogue Number:B408500
Chemical Name:1,4-Bis(benzhydryl)piperazine
Synonyms:1,4-Bis(diphenylmethyl)piperazine; 1,4-Bisbenzhydrylpiperazine; Cinnarizine EP Impurity E;
Impurity:Cinnarizine EP Impurity E
CAS Number:216581-01-0
Alternate CAS #
HCl Salt: 56265-29-3
Molecular Formula:C₃₀H₃₀N₂
Appearance:White to Off-White Solid
Melting Point:>235°C (dec.)
Molecular Weight:418.57
Storage:4°C
Solubility:Chloroform (Slightly), DMSO (Slightly, Heated)
Stability
Light Sensitive
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:1,4-Bis(benzhydryl)piperazine is a cinnarizine (C465300) impurity. Cinnarizine is an anti-vasoconstricting agent (1), as well as a calcium channel blocker (2,3) with antiallergic activity. Antihistaminic.
References:Zhang, H., et al.: Biochemistry, 43, 8290 (2004); Pandey, A., et al.: J. Pharm. Biomed. Anal., 20, 203 (1999); Andrews, S., et al.: J. Med. Chem., 53, 916 (2010);
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