CAS:21472-89-9|1-Azabicyclo[2.2.1]heptan-3-one

Catalogue Number:B408125
Chemical Name:1-Azabicyclo[2.2.1]heptan-3-one
CAS Number:21472-89-9
Molecular Formula:C₆H₉NO
Molecular Weight:111.14
Category:Building Blocks; Miscellaneous;
Applications:1-Azabicyclo[2.2.1]heptan-3-one (CAS# 21472-89-9) can be used in the preparation of spirocyclic quinuclidinyl-Δ2-isoxazolines as neuronal nicotinic acetylcholine receptor agonists. It can also be used in the preparation of isoquinoline derivatives as progranulin modulators useful in treatment of progranulin-associated disorders. Useful in the preparation of N-pyridinyl carboxamides as cyclin-dependent kinase inhibitors. Useful in the preparation of glucosylceramide synthase inhibitors for treatment of metabolic diseases, such as lysosomal storage diseases.
References:Dallanoce, C., et. al.: Eur. J. Med. Chem., 46, 5790 (2011); Burnett, D. A., et. al.: PCT Int. Appl., 293pp. (2020); Heiser, U. et. al.: PCT Int. Appl., 125pp. (2011); Leonard, J. P., et. al.: PCT Int. Appl., 210pp. (2015)
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