Catalogue Number:B394750
Chemical Name:N-Biotinylaminoethyl Methanethiosulfonate
Synonyms:Methanesulfonothioic Acid S-[2-[[5-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethyl] Ester; MTSEA-BIOTIN;
CAS Number:162758-04-5
Molecular Formula:C₁₃H₂₃N₃O₄S₃
Appearance:White to Off-White Solid
Melting Point:95-103°C
Molecular Weight:381.53
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Moisture Sensitive
Category:Research Tools; Cross-linkers; Sulfhydryl Active Reagents;
Applications:Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease. MTSEA-biotin has recently been used to probe the topology of the serotonin (5-HT) transporter by site-directed chemical labelling.
References:J. Biol. Chem., 273(20), 12675 (1998), Adams, C.M., et al.: J. Biol. Chem., 273 (46), 30204 (1998), Boileau, A. J., et al.: J. Neurosci., 19, 12, 4847 (1999), Wagner, D.A.and Czajkowski, C.: J. Neurosci., 21, 67 (2001), Traebert, M.: J. Membr. Biol., 180, 83 (2001)
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