Catalogue Number:B377008
Chemical Name:BIBU 1361 Dihydrochloride
Synonyms:N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-amine Dihydrochloride
CAS Number:1643609-75-9
Alternate CAS #
Free Base: 793726-84-8
Molecular Formula:C₂₂H₂₇ClFN₇ • 2(HCl)
Appearance:Light Yellow to Dark Orange Solid
Molecular Weight:443.95 + 2(36.46)
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Very Slightly)
Category:Standards; Enzyme Activators and Inhibitors;
Applications:BIBU 1361 Dihydrochloride, is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). It also blocks downstream EGFR signaling events such as MAPKK/MAPK activation.
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