CAS:58917-67-2|Benzo[a]pyrene Diol Epoxide (>90%)

Catalogue Number:B287550
Chemical Name:Benzo[a]pyrene Diol Epoxide (>90%)
Synonyms:(7R,8S,8aS,9aR)-rel-7,8,8a,9a-Tetrahydrobenzo[10,11]chryseno[3,4-b]oxirene-7,8-diol; (7?,8?,8a?,9a?)-7,8,8a,9a-Tetrahydrobenzo[10,11]chryseno[3,4-b]oxirene-7,8-diol; ()-7?,8?-Dihydroxy-9?,10?-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; ()-7?,8?-Dihydroxy-9?,10?-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; ()-anti-BPDE; anti-Benzo[a]pyrene-7,8-diol-9,10-epoxide; trans-7,8-Dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene;
CAS Number:58917-67-2
Molecular Formula:C₂₀H₁₄O₃
Appearance:Pale Yellow to Yellow Solid
Melting Point:164-166C
Molecular Weight:302.32
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Light Sensitive
Category:Standards; Environmental Standards, Mutagens and Metabolites;
Applications:Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway. Benzo [a]pyrene diol epoxide (BPDE), a carcinogen present in tobacco smoke as well as in environmental pollution, induces esophageal carcinogenesis.
References:Cavalieri, E., et al.: Biochem. Pharmacol., 1988, 37, 2173 (1988); Conney, A., et al.: Cancer Res., 42, 4875 (1982); Penning, T., et al.: Chem. Res. Toxicol., 9, 84 (1996); Lu, D., et al.: Chem. Res. Toxicol., 2011, 24, 1905 (2011);
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