Chemical Name:(2R,3S,11bR)-Dihydrotetrabenazine
Synonyms:(2R,3S,11bR)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol
CAS Number:862377-31-9
Molecular Formula:C₁₉H₂₉NO₃
Molecular Weight:319.44
Category:Research Tools; Standards; Molecular Biology; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(2R,3S,11bR)-Dihydrotetrabenazine is an enantiomer of (2S,3R,11bS)-Dihydrotetrabenazine (D454920). Tetrabenazine and dihydrotetrabenazines are potent inhibitors of vesicular monoamine transporter 2 (VMAT2). Furthermore, the derivatives of these compounds are potential drug candidates for treating various diseases such as Huntington’s disease and other hyperkinetic disorders.
References:Yao, Z., et al.: Eur. J. Med. Chem. 46, 1841 (2011); Duffield, A. J. and Williams, N. A. PCT Int. Appl. WO 2010026434 A1 20100311(2010); Grayson, B. et al.: PCT Int. Appl. WO 2009150474 A1 20091217 (2009); Nichols, P. P. Brit. UK Pat. Appl. GB 2463451 A 20100317 (2010)
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