Catalogue Number:B278500
Chemical Name:O6-Benzylguanine
Synonyms:6-(Phenylmethoxy)-9H-purin-2-amine; 2-Amino-6-(benzyloxy)purine; NSC 637037;
CAS Number:19916-73-5
Molecular Formula:C₁₂H₁₁N₅O
Appearance:Off-White to Yellow Solid
Melting Point:>193°C (dec.)
Molecular Weight:241.25
Storage:-20°C
Solubility:Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly)
Category:Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;
Applications:An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents.
References:Dolan, M.E., et al.: Proc. Natl. Acad. Sci. USA, 87, 5356 (1990), Goodtzova, K., et al.: Biochemistry, 33, 385 (1994), Elder, R.H., et al.: Biochem. J., 298, 231 (1994)
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