Catalogue Number:B216130
Chemical Name:Basimglurant
Synonyms:2-Chloro-4-[2-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-yl]ethynyl]pyridine; 2-Chloro-4-[2-[1-(4-fluorophenyl)-2,5-dimethylimidazol-4-yl]ethynyl]pyridine; RG 7090;
CAS Number:802906-73-6
Molecular Formula:C₁₈H₁₃ClFN₃
Appearance:Pale Brown to Light Brown Solid
Melting Point:132 – 135°C
Molecular Weight:325.77
Storage:-20°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Hygroscopic, Moisture Sensitive
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Basimglurant is a potent, selective and orally available mGlu5 negative allosteric modulator for the treatment of mood disorders.
References:Henter, I. D., et al.: CNS Drugs, 35, 527 (2021); Bennett, K. A., et al.: J. Pharmacol. Exp. Ther., 377, 157 (2021)
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